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KMID : 1144520190310010044
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Knee Surgery & Related Research
2019 Volume.31 No. 1 p.44 ~ p.53
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Intra-articular Recombinant Human Growth Hormone Injection Compared with Hyaluronic Acid and Placebo for an Osteoarthritis Model of New Zealand Rabbits
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Lubis Andri Maruli Tua
Wonggokusuma Erick
Marsetio Aldo Fransiskus
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Abstract
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Purpose: Up to now, there is no feasible solution for stopping or reversing the degenerative process of osteoarthritis (OA). Our study evaluated the effect of intra-articular injection of growth hormone (GH) in OA-induced rabbit knees compared to hyaluronic acid (HA) and placebo.
Materials and Methods: A total of 21 male, skeletally mature, New Zealand rabbits received an intra-articular type II collagenase injection for OA induction. Two weeks later, the rabbits were randomized into three groups based on the weekly intra-articular injection to be received: GH, HA, and saline. Injections were done for three consecutive weeks. Evaluation was done at 8 weeks after treatment, clinically using the lameness period, macroscopically using the Yoshimi score and microscopically using the Mankin score.
Results: The shortest period of lameness was found in the GH group (15.9±2.12 days), compared to the HA group (19.4±1.72 days) and placebo group (25.0±2.94 days). There was a statistically significant difference in macroscopic scoring between groups (p=0.001) in favor of the GH group. There was also significant difference in the microscopic score between groups (p=0.001) also in favor of the GH group.
Conclusions: Intra-articular injection of GH showed better clinical, macroscopic and microscopic results as compared to HA and placebo.
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KEYWORD
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Knee, Osteoarthritis, Growth hormone, Hyaluronic acid
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